About Evommune, Inc.

Evommune, Inc. is a private clinical-stage biotechnology company dedicated to revolutionizing the treatment of immune-mediated inflammatory diseases. Founded in 2020 by a leading team of R&D experts and biotech innovators, Evommune is headquartered in Palo Alto, California, with additional offices in New York, NY. Through groundbreaking science, we are committed to discovering, developing, and delivering therapies that not only address symptoms but also halt disease progression. Our pipeline focuses on advancing novel treatment options for underserved patient populations, targeting diseases at their root with best-in-class agents for safety and efficacy. For more information, visit www.Evommune.com.

This hybrid position is currently expected to be in the office 2 days a week with the option of working remotely 3 days a week. The position reports to the Executive Director, Non-Clinical Development. This is a unique opportunity to join an innovative biotech developing novel therapeutics for chronic inflammatory diseases. Evommune’s pipeline is focused on advancing new treatment options in underserved patient populations. We target these pathologies at the source, with novel agents that exhibit best-in-class profiles for safety and efficacy, delivering therapeutics for patients that go beyond symptomatic relief.

Our core values

Before we dive into the specifics of the role, it's important to highlight the core values that are integral to being a member of the Evommune team. Our values are not just words; they shape our culture, guide our decision-making, and define what it means to be part of our team.

• Together We Win: We champion teamwork, celebrating every achievement as a shared success.
• Guided by Insight: We make data-driven decisions, using our collective experience to shape the future of our business.
• Every Day Matters: We act with urgency to bring transformative therapies to patients by being nimble, decisive, and effective.
• Driven By Excellence: We set a high bar and hold ourselves accountable to deliver exceptional results in everything we do.

Empowered To Act: We invest in our team and value transparency, fostering trust and a sense of ownership.

We seek individuals who resonate with these principles, as they are essential for thriving in our collaborative, innovative, and dynamic work environment.

About the role

As the Director of DMPK, you will be responsible for providing scientific and technical leadership in ADME/PK/PK-PD strategy for small molecules to support drug discovery and development. You will lead critical DMPK efforts from discovery through clinical development, including first-in-human (FIH) dose predictions and preparation of regulatory documents. This role requires exceptional scientific expertise, collaboration skills, and the ability to influence decision-making to advance our programs.

We are looking for a strong leader with a proven track record, excellent problem-solving capabilities, and a commitment to quality to shape and drive the DMPK strategy. If you thrive in a hands-on, innovative environment, we want to hear from you.

What you'll do

• Provide expert technical and scientific leadership in pharmacokinetics, pharmacodynamics, drug metabolism, and bioanalytical methodologies.
• Develop and implement DMPK and PK-PD strategies that align with Evommune’s drug discovery and development objectives.
• Serve as DMPK lead on cross-functional discovery and development project teams.
• Collaborate with internal teams, including medicinal chemistry, pharmacology, toxicology, clinical, and CMC, to support program progression.
• Design, execute, and interpret DMPK studies, ensuring timely communication of results to project teams, senior leadership, and external stakeholders.
• Oversee relationships with CROs, consultants, and external partners to enhance DMPK resources and capabilities.
• Author or contribute to DMPK sections of regulatory filings (e.g., IND, CTA), ensuring compliance with global regulatory guidelines.
• Provide FIH dose projections and guide translation from preclinical to clinical studies.
• Address emerging needs and responsibilities related to DMPK as the organization grows and evolves.

Qualifications

• PhD in pharmacokinetics, drug metabolism, or a related discipline.
• 10+ years of experience in small molecule DMPK within the pharmaceutical or biotechnology industry and a strong track record of leading DMPK efforts to advance drug development programs.
• Demonstrated expertise in clinical candidate selection and preclinical-to-clinical translation.
• Experience designing and conducting studies to understand drug disposition profiles and PK-PD relationships.
• Proficiency in PK and PK-PD data analysis using specialized software.
• Direct experience in regulatory submissions, including authoring DMPK sections for IND, IMPD, and NDA/BLA filings.
• Deep understanding of regulatory guidelines to support small molecule drug development and interactions with global regulatory agencies.
• Hands-on experience with bioanalytical method development, validation, and PK analysis.
• Exceptional organizational, analytical, and problem-solving skills, with an attention to quality and documentation.

Leadership Attributes

• Act as a key, influential leader, driving the DMPK agenda in collaboration with senior leadership.
• Exhibit exceptional written, verbal, and interpersonal communication skills to convey technical information effectively.
• Lead with a hands-on, detail-oriented, and results-driven approach in a fast-paced, team-oriented environment.
• Inspire and mentor team members while fostering a culture of innovation, collaboration, and excellence.

Compensation

The salary range for this position is $190,000-$240,000 and the position may be eligible for performance-based bonuses and/or equity-linked compensation. Salary ranges are determined by role, level and location and additional factors, including job-related skills, experience, and relevant education or training. We offer Company-sponsored benefits, which include: comprehensive health, dental and vision plans, and pet insurance. In addition, we provide a 401(k) plan, ample time off programs, paid parental leave, life insurance, disability insurance and an employee referral bonus program.

Evommune is proud to be an equal opportunity employer and will consider all qualified applicants for employment.

In accordance with the Company’s determination to provide and maintain a safe workplace, the Company requires all employees to be Fully Vaccinated against COVID-19 with one of the FDA approved COVID-19 vaccines, which includes those vaccines that have received the FDA’s emergency use authorization. You will be expected to be Fully Vaccinated as of your Start Date. If you believe that you are exempt from this requirement under an applicable law or regulations, including Americans with Disabilities Act and California’s Fair Employment and Housing Act, you will need to contact the Company’s Human Resources group. For purposes of this section, Fully Vaccinated means (i) the completion of the vaccination regimen as approved by the FDA (by way of example, 2 doses of the Pfizer or Moderna vaccine and 1 dose of the Johnson and Johnson vaccine), and (ii) timely receiving booster vaccination, as guided by your licensed healthcare provider and/or any applicable laws/regulations.