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Amplitude Ventures
Amplitude Ventures

Director, Data Science

Notch Therapeutics

Notch Therapeutics

Data Science
Seattle, WA, USA
Posted on Saturday, April 6, 2024

Role Summary

The Director, Data Science will be a key leader in the organization, reporting to the Chief Scientific Officer (CSO). The Director will oversee all Data Science and Bioinformatics programs and be part of a diverse team focused on advancing iPSC-derived T-cell therapeutics from discovery-stage through scale-up and clinical manufacturing. They will provide deep technical knowledge and hands-on expertise in developing genomic analysis workflows and databases. They will be responsible for task definition, planning, execution and reporting of internal and partner-facing projects. They will be a leader in bringing new and innovative products, technologies and processes to market to enable life-saving advances in cell therapy.


Seattle, WA.

Key Responsibilities

  • PK/PD modeling with an emphasis on cell therapy
  • Development and application of mechanistic models of cellular dynamics
  • Bioinformatics; processing and analytics high dimensional data sets including WGS, mRNA sequencing, single cell data sets, CITE-Seq, Multiplexed Spatial proteomics, Cellular interaction networks
  • Development of methods for storage and analysis of multidimensional data sets
  • Application of novel data analysis methodologies to complex datasets including machine learning or other adaptive non-biased approaches to data set analysis
  • Work closely with Process Development to analyze time course datasets, such as gene expression during differentiation, in-process measurements of cell culture status (cell count, viability, glucose/lactate etc.), and endpoint measurements of potency to gain insight into processing parameters and cell characteristics driving successful T cell production from iPSCs
  • Work closely with the CSO and academic and industry partners as well as represent Notch at key scientific and industry conferences
  • Responsible for budget and personnel management

Qualifications and Experience

  • Ph.D. in Bioinformatics, Data Science or related fields.
  • 10+ years pharmaceutical or biotechnology industry experience leading teams from discovery through IND.
  • Demonstrated experience leading cross functional project teams.
  • Strong patent and/or publication record.
  • Ability to travel to Notch Canadian offices.

Desired Characteristics and Demonstrated Skills

Demonstrated ability and keen interest in modelling Notch’s Core Values: Collaborative, Motivated, Ingenious.

Salary Range: $200,000 - $260,000


  • Paid Vacation and Sick time
  • Hybrid Work Framework
  • Healthcare plans
  • 401k/RRSP plan
  • Commuting Financial Assistance
  • Home Office WIFI Support
  • Employee assistance programs (EAPs)
  • Internal learning & development opportunities

Notch Therapeutics Inc. is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, age, gender identity, sexual orientation, color, religion, sex, marital status, national origin, protected veteran status, disability status, or any other status protected by federal, provincial or local law.

Requests for accommodation can be made at any stage of the recruitment process providing the applicant has met the Bona-fide requirements for the open position. Applicants need to make their requirements known when contacted.