About Notch (www.notchtx.com)

Notch is an early-stage biotech company, working to maximize the benefit of cell therapies through a proprietary T cell-production platform which combines sophisticated product design with commercial-compatible processes to enhance patient outcomes. Notch’s iPSC-based technology platform allows for precision control of notch signaling, which removes several critical limiting factors in the development of cell therapies, delivering the ability to design and manufacture a uniform and unlimited supply of therapeutic T cells.

Role Summary

The candidate will be part of the Preclinical Sciences group in Seattle. The individual will have an opportunity to lead a passionate group of scientists and shape the science and culture of Notch’s research group in a tangible way. The ideal candidate will be technically sound at planning and executing a suite of immunological assays to characterize engineered effector cells. The individual will be responsible for supporting our efforts to develop appropriate armoring strategies to improve the function of effector cells that are generated by Notch’s differentiation process. This role will help leverage an understanding of immune responses to solid and hematological tumors and help define product strategy to improve the efficacy of iPSC derived cell products. Through cross functional collaboration the Senior Scientist will contribute to the design and development of novel product designs for executing towards our pipeline initiatives.

Key responsibilities:

• Lead a project team to perform in depth functional characterization of our iPSC derived effector cells.
• Leverage T cell biology, tumor biology, tumor microenvironment expertise in collaborative efforts with scientists to investigate, develop and implement novel strategies for armoring iPSC derived effector cell products.
• Analyze data, interpret results, and present findings for both internal and external audiences. Integrate findings to identify next logical steps and participate in development of novel intellectual property for enhancing T-cell efficacy.
• Assist with oversight of experimental design, data integrity and interpretation reported by team members.
• Work as a part of cross-functional and cross-site groups to execute larger company endeavors and goals.
• Contribute to strategic directions by identifying technologies that can add new capabilities.
• Spend at least 50% of their time at the bench and maintain electronic laboratory notebooks, other documentation as need for regulatory filings.

Role Requirements and Qualifications

• Typically, a PhD in Immunology or Cancer biology with 8+ years of post-doc/industry experience

Desired Characteristics and Demonstrated Skills

• Demonstrate ability and keen interest in modelling Notch’s Core Values: Collaborative, Motivated, Ingenious
• Experience in hiring, supervising, developing and evaluating employees in a matrix environment.
• Experience leading a multi-disciplinary team of scientists and engineers focused on delivery against milestones.
• Experience with developing timelines and executing successfully on corporate objectives.
• Decisive, proactive, and organized with a keen ability to prioritize.
• Open-minded and risk-tolerant and not afraid to push or be challenged.
• High scientific integrity, committed to ethics and scientific rigor.
• Excellent verbal and written communication skills with the demonstrated ability to make effective presentations to a broad range of audiences, both internal and external.
• Exhibits deep subject matter expertise in general immunology, T/NK cell biology and immuno-oncology.
• Technical expertise in core methodologies commonly used to evaluate functional characteristics of cellular therapy products (Incucyte, MSD, flow cytometry, IsoPlexis etc.).
• Experience managing complex projects with multiple people/teams.

Salary Range: $150,000 - $190,000

Benefits:

• Paid Vacation and Sick time
• Hybrid Work Framework
• Healthcare plans
• 401k/RRSP plan
• Commuting Financial Assistance
• Home Office WIFI Support
• Employee assistance programs (EAPs)
• Internal learning & development opportunities

Notch Therapeutics Inc. is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, age, gender identity, sexual orientation, color, religion, sex, marital status, national origin, protected veteran status, disability status, or any other status protected by federal, provincial or local law.

Requests for accommodation can be made at any stage of the recruitment process providing the applicant has met the Bona-fide requirements for the open position. Applicants need to make their requirements known when contacted.