We are seeking a hands-on Senior Scientist to join our growing team as an early and foundational hire. In this role you will help establish our laboratory infrastructure, support large-scale phenotypic screens, and develop the cell-based assay capabilities that will underpin our small molecule programs. As the company matures, this person will take increasing ownership of SAR-supporting assays and be a key partner in advancing compounds through early drug discovery. The role is full-time and on-site in Montreal.

Key Responsibilities

Support the design and execution of large-scale pooled phenotypic screens in primary human immune cells, including cell culture, assay setup, and data collection.
Collaborate with the broader biology and computational teams to connect screen outputs to target validation
Develop, optimize, and implement biophysical and cell-based assays to support compound progression from hit validation through drug candidate nomination.
Interpret experimental results to advance understanding of target biology and pharmacology
Develop and rigorously maintain SOPs, experimental records, and reproducible protocols to support a high-quality research environment
Help establish and organize the lab from the ground up, including equipment procurement, vendor relationships, reagent management, and safety compliance

Ideal Candidate

Ph.D. in a relevant discipline with 3-5 years of drug discovery experience in a pharmaceutical or biotech environment; or M.Sc. with 5-10 years of similar experience
Strong hands-on experience developing a range of biochemical and cellular assays used to support small molecule profiling for both first-in-class and best-in-class targets
Extensive experience in molecular and cell biology techniques including ELISA, Western blotting, MSD, flow cytometry, quantitative PCR, biochemical/cell-based assays to measure metabolites and enzymatic activity (colorimetric, fluorometric and luminescence-based) and biophysical assays to measure protein binding (ex: HTRF)
Comfortable with primary cell culture and immune cell assay systems; flow cytometry experience is a plus
Prior experience setting up or managing an industry lab in an asset
Highly organized and detail-oriented; able to manage multiple workstreams simultaneously in an early-stage environment